研究成果

主持项目:

1.      浙江省自然科学基金面上基金项目,LY18H300008,针对蛋白质精氨酸甲基转移酶PRMT1的药物发现与化学干预研究,2018/01-2020/1210万元、在研、主持。

2.      国家自然科学基金青年科学基金项目,81402849,靶向menin-MLL相互作用界面的药物发现与药物设计,2015/01-2017/1223万元、在研、主持。

3.      浙江省科技计划公益类项目,2015C33159,基于金黄色葡萄球菌ClpP的抗菌药物发现与药物设计,2015/04-2017/0615万元、已结题、主持。

4.      浙江省自然科学基金青年科学基金项目,LQ14H300003,基于DNA甲基转移酶DNMT1的抗肿瘤药物发现与药物设计,2014/01-2016/125万元、已结题、主持。

5.      浙江理工大学521人才中青年骨干人才培养计划,4万元、主持

6.      新药研究国家重点实验室开放课题,SIMM1403KF-06,靶向Menin-MLL 相互作用的药物设计与药物发现,2014/04-2015/058万元、已结题、主持。

7.  配受体复合物HJ24-SHP2解离顺序的单分子力谱研究,国家自然科学基金,2015.01-2017.1223万元、第二参与。

发表论文(第一作者或通讯作者):

1.   Fei Ye, Xiangqian Kong, Hao Zhang, Yan Liu, Zhiyuan Shao, Jia Jin, Yi Cai, Rukang Zhang, Linjuan Li, Yang W. Zhang, Yu-Chih Liu, Chenhua Zhang, Wenbing Xie, Kunqian Yu, Hong Ding, Kehao Zhao, Shijie Chen*, Hualiang Jiang, Stephen B. Baylin* and Cheng Luo*. Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNMT1. ACS Chemical Biology, 13(3):772-781, 2018. (IF=4.995)

2.       Chen Wang, Hao Jiang, Jia Jin, Yiqian Xie, Zhifeng Chen, Hao Zhang, Fulin Lian, Yu-Chih Liu, Chenhua Zhang, Shijie Chen, Naixia Zhang, Yuanyuan Zhang, Hualiang Jiang, Kaixian Chen, Fei Ye*, Zhiyi Yao* and Cheng Luo*. Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors Inhibiting Leukemia Cells Proliferation. Journal of Medicinal Chemistry, 60 (21): 8888–8905, 2017. (IF=6.259)  

3.       Weiyao Zhang, Wenchao Lu, Hao Jiang, Yiqian Xie, Fulin Lian, Zhongjie Liang, Dajin Wang, Cheng Luo, Jia Jin, and Fei Ye*. Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors. Chemical Biology & Drug Design, 90(6):1260-1270, 2017.

4.       Tengfeng Ni1, Fei Ye1, Xing Liu, Jie Zhang, Hongchuan Liu, Jiahui Li, Yingyi Zhang, Yingqiang Sun, Meining Wang, Cheng Luo, Hualiang Jiang, Lefu Lan, Jianhua Gan, Ao Zhang, Hu Zhou, and Cai-Guang Yang. Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure. ACS Chemical Biology, 11(7):1964-72, 2016. (IF=4.995)

5.       Liyan Yue1, Juanjuan Du1, Fei Ye1, Zhifeng Chen, Lianchun Li, Fulin Lian, Bidong Zhang, Yuanyuan Zhang, Hualiang Jiang, Kaixian Chen, Yuanchao Li, Bing Zhou, Naixia Zhang, Yaxi Yang* and Cheng Luo*. Identification of novel small-molecule inhibitors targeting menin–MLL interaction, repurposing the antidiarrheal loperamide. Organic & Biomolecular Chemistry, 14(36):8503–8519, 2016. (Co-first author)

6.       Fei Ye, Weiyao Zhang, Wenchao Lu, Yiqian Xie, Hao Jiang, Jia Jin*, and Cheng Luo. Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays. BioMed Research International, 2016:7086390, 2016.

7.       Fei Ye, Jiahui Li, Cai-Guang Yang*. The development of small-molecule modulators for ClpP protease activity. Molecular Biosystems, 13(1):23-31, 2016.

8.       Fei Ye, Liyi Zhang, Lu Jin, Mingyue Zheng, Hualiang Jiang and Cheng Luo*. Repair of methyl lesions in RNA by oxidative demethylation. Med. Chem. Commun., 5: 1797-1803, 2014

9.       Lu Jin1, Fei Ye1, Dan Zhao, Shijie Chen,  Kongkai Zhu, Mingyue Zheng, Ren-Wang Jiang, Hualiang Jiang, and Cheng Luo*. Metadynamics Simulation Study on the Conformational Transformation of HhaI Methyltransferase: An Induced-Fit Base-Flipping Hypothesis. BioMed Research International, 2014:304563, 2014. (Co-first author)

10.   Lianchun Li, Ran Zhou , Heji Geng , Liyan Yue , Fei Ye*, Yiqian Xie , Jingqiu Liu , Xiangqian Kong ,Hualiang Jiang, Jiandong Huang , Cheng Luo*. Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin–mixed lineage leukaemia interface. Bioorganic & Medicinal Chemistry Letters, 24: 2090–2093, 2014. (Corresponding author)

11.   Fei Ye1, Jie Zhang1, Hongchuan Liu, Rolf Hilgenfeld, Ruihan Zhang, Xiangqian Kong, Lianchun Li, Junyan Lu, Xinlei Zhang, Donghai Li, Hualiang Jiang*, Cai-Guang Yang*, and Cheng Luo*. Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus CLP protease. Journal of Biological Chemistry, 288(24):17643-17653, 2013. (IF=4.125)

12.   Baoen Chen1, Fei Ye1, Lu Yu1, Guifang Jia, Xiaotian Huang, Xueju Zhang, Shuying Peng, Kai Chen, Meining Wang, Shouze Gong, Ruihan Zhang, Jinya Yin, Haiyan Li, Yiming Yang, Hong Liu, Jiwen Zhang, Haiyan Zhang, Ao Zhang, Hualiang Jiang, Cheng Luo*, and Cai-Guang Yang*. Development of Cell-active N6-Methyladenosine RNA Demethylase FTO Inhibitor. Journal of the American Chemical Society, 134(43): 17963–17971, 2012. (IF=13.858)

13.   Jie Zhang1, Fei Ye1, Lefu Lan, Hualiang Jiang, Cheng Luo*, Cai-Guang Yang*. Structural Switchings Of Staphylococcus Aureus ClpP: A Key To Understanding Protease Mechanism, Journal of Biological Chemistry, 286(43): 37590-37601, 2011. (IF=4.125)

14.   Fei Ye, Xiangqian Kong, Cheng Luo*. Advance in the Study of Mechanisms regulatd by Sphingosine-1-Phosphate. Bulletin of National Natural Science Foundation of China, 18(1): 57-60, 2010.

15.   Fei Ye, Weiyao Zhang, Xiaoqing Ye, Jia Jin, Zhengbing Lv, Gang Chen, Qinghe Zhou, Cheng Luo*. Identification of Selective and Cell Active Inhibitors of Protein Arginine Methyltransferase 5 (PRMT5) through Structure-Based Virtual Screening and Biological Assays. Journal of Chemical Information and Modeling, revised.

16.  专利:大黄酸或大黄酸类化合物在制备治疗以FTO为靶点的疾病的药物中的用途;专利号:201210197108;公开日:2012.10.03

 

 

姓名:叶飞

性别:女

所在部门:生命科学学院

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专业技术职务:副教授

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» 生物学

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