科研课题

1. 国家自然科学基金青年项目，胚胎组织来源不同的额骨和顶骨的转录组表达谱的差异分析及其在头颅骨发育中的作用，23万元，主持

2. 美国Craig H. Neilsen Foundation，脊髓损伤下神经轴突的蛋白合成和降解功能研究，30万美金，参与

3. 浙江省公益技术研究计划，Nf2介导的内源性骨再生对损伤性骨组织修复和再生的分子机制，10万，主持

4. 浙江省人力资源与社会保障厅，Nf2联动Hippo和TGF-beta信号通路调控颅骨发育的分子机制研究。5万，主持

5. 一种促骨再生愈合药物的分子机制研究，合作项目，14万，主持

6. 骨肽制剂在骨质疏松模型中的治疗效果评估与分析，合作项目，20万，主持

7. 省自然科学基金重点项目，Nf2-FAK信号轴调控颅骨缺损再生的分子机制研究，30万，主持

8. 颅面骨出生缺陷基因诊断产品开发，合作项目，50万，主持

代表性文章（*通讯）

13. Rexhina Vlashi, Xingen Zhang, Mengrui Wu, Guiqian Chen*, Wnt signaling: essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders. Genes & Diseases, 2022 (IF 7.26)

12. J Liao, Y Huang, Q Wang, S Chen, C Zhang, D Wang, Z Lv, XZhang, M Wu, G Chen*. Gene regulatory network from cranial neural crest cells to osteoblast differentiation and calvarial bone development. Cellular and Molecular Life Sciences, 2022 (IF 9.26)

11. M. Ishan, G. Chen, W. Yu, Z. Wang, M. Giovannini, X. Cao, H.X. Liu, Deletion of Nf2 in neural crest-derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region- and stage-specific manner, Cell Prolif (2021) e13144 (IF 6.81)

10. S.N. Juma, X. Gong, S. Hu, Z. Lv, J. Shao, L. Liu, G. Chen*, Shark New Antigen Receptor (IgNAR): Structure, Characteristics and Potential Biomedical Applications, Cells 10(5) (2021) (IF 6.6)

9. M. Liu, Y. Hu, G. Chen*, The Antitumor Effect of Gene-Engineered Exosomes in the Treatment of Brain Metastasis of Breast Cancer, Front Oncol 10 (2020) 1453 (IF 6.24)

8. M. Ishan, G. Chen, C. Sun, S.Y. Chen, Y. Komatsu, Y. Mishina, H.X. Liu, Increased activity of mesenchymal ALK2-BMP signaling causes posteriorly truncated microglossia and disorganization of lingual tissues, Genesis 58(1) (2020) e23337 (IF 2.48)

7. G. Chen*, H. Xu, Y. Yao, T. Xu, M. Yuan, X. Zhang, Z. Lv, M. Wu, BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells, Front Cell Dev Biol 8 (2020) 135 (IF 6.68)

6. G. Chen*, Y. Yao, G. Xu, X. Zhang, Regional difference in microRNA regulation in the skull vault, Dev Dyn 248(10) (2019) 1009-1019 (IF 3.78)

5. X. Zhang, G. Shi, X. Sun, W. Zheng, X. Lin, G. Chen*, Factors Influencing the Outcomes of Artificial Hip Replacements, Cells Tissues Organs 206(4-5) (2018) 254-262 (IF 2.48)

4. T. Wu, G. Chen*, F. Tian, H.X. Liu, Contribution of cranial neural crest cells to mouse skull development, Int J Dev Biol 61(8-9) (2017) 495-503 (IF 2.2)

3. G. Chen, M. Ishan, J. Yang, S. Kishigami, T. Fukuda, G. Scott, M.K. Ray, C. Sun, S.Y. Chen, Y. Komatsu, Y. Mishina, H.X. Liu, Specific and spatial labeling of P0-Cre versus Wnt1-Cre in cranial neural crest in early mouse embryos, Genesis 55(6) (2017) (IF 2.48)

2. M. Wu, G. Chen, Y.P. Li, TGF-beta and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease, Bone Res 4 (2016) 16009 (IF 13.57)

1. G. Chen, C. Deng, Y.P. Li, TGF-beta and BMP signaling in osteoblast differentiation and bone formation, Int J Biol Sci 8(2) (2012) 272-88 (IF 6.58)

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