研究成果
我的研究成果:
一、 主持及参与项目:
1、次生代谢物质量控制与检测技术标准研究,国家级重点子课题任务,主持;
2、基于Aβ25-35诱导PC12细胞氧化损伤保护作用的2种五加叶药效物质基础、构效关系及机制研究,浙江省自然科学基金,主持;
3、新型透皮吸收抗氧化药物的制备技术开发,横向,主持;
4、透皮吸收剂型抗氧化药物活性测定,横向,主持;
5、韩国国家食品药品安全厅“对照生药材基源鉴定,制造及资源再评价”、韩国保健福祉部“韩药材评价技术科学化研究”、“韩国药材生理活性分析及含量监测研究”等,参与;
6、韩国东亚制药公司“基于朝鲜淫羊藿抗阿尔茨海莫病的新药开发与研究”项目,参与;
7、肿瘤靶标蛋白TNIK磷酸化促乳腺癌生长转移机制及其靶向抑制剂研究,国家级一般,参与;
8、负调控因子SmMYB39与正调控因子SmbHLH7协同调控丹参酚酸类成分生物合成的分子机制,国家级一般, 参与.
9、铁皮石斛、三七、半夏转录组测序及开发应用,横向,130万元,参与;
10、乳核散结胶囊标准提高及标准化建设项目,横向,20万元,参与;
11、珍稀中药材高效组培繁育技术及相关产品开发,横向,20万元,参与;
二、已发表的论文:
(1) Xiaodan Zhang#, Yange Yu#, Dongfeng Yang, Zhechen Qi, Ruizhen Liu, Fengtao Deng, Zengxuan Cai, Ying Li, Yanfang Sun*, and Zongsuo Liang*, Chemotaxonomic variation in secondary metabolites contents and their correlation between environmental factors in Salvia miltiorrhiza Bunge from natural habitat of China, IND CROP PROD, 2018, 113, 335-347.(Top 期刊)
(2) Xiaodan Zhang#, Yange Yu#, Yesheng Cen, Dongfeng Yang, Zhechen Qi, Zhuoni Hou, Shuanglai Han, Zengxuan Cai, and Kuancheng Liu*, Bivariate Correlation Analysis of the Chemometric Profiles of Chinese Wild Salvia miltiorrhiza Based on UPLC-Qqq-MS and Antioxidant Activities, Molecules, 2018,23,538.
(3) Xiaodan Zhang#, Zhi Li#, Guozhu Liu, Xiang Wang, Okkyoung Kwon, Hyeongkyu Lee, Wankyunn Whang, and Xiangqian Liu*, Quantitative determination of 15 bioactive triterpenoid saponins in different parts of Acanthopanax henryi by HPLC with charged aerosol detection and confirmation by LC-ESI-TOF-MS, Journal of seperation science, 2016, 39 (12), 2252-2262.
(4) Xiaodan Zhang, Xinqi Zhou, Xiangqian Liu, Xiaolong Li, and Wankyunn Whang, Development and Application of an HPLC-UV Procedure to Determine Multiple Flavonoids and Phenolics in Acanthopanax Leaf Extracts, J CHROMATOGR SCI, 2015, 54 (4), 574-582.
(5) Xiaodan Zhang, Xiangqian Liu, Y.H. Kim,and Wankyunn Whang* Chemical constituents in leaves of Acanthopanax henryi and antioxidant and acetyl cholinesterase inhibitory activities of some their major metabolites: A Potential Complementary Source against Alzheimer’s Disease. Archives of Pharmacal Research 2014,37(15):606-616.
(6) Xiaodan Zhang#, Mihyue Oh,Seulgi Kim, Jimin Kim, Hyeyeon Kim, Sungun Kim, Peter J. Houghton,and Wankyunn Whang *. Epimediphine, a novel alkaloid from Epimedium koreanum inhibits acetylcholinesterase. Natural Product Research 2013, 27(12): 1067-1074.
(7)Li X.J.,Dai L.,Li Z.,Zhang X.D.,Liu X.Q.,Zou Q.P.,and Xie X. 2015. Anti-inflammatory Activities of Lupane-triterpenoids In Vitro and Their Phytochemical Fingerprinting from Leaves of Acanthopanax gracilistylus. Natural Product Sciences 21(2) : 104-110.
(8) Li X.J.,Huang W.C.,Li Z.,Zhang X.D.,Liu X.Q.,Kwon O.K.,Lee H.K. 2015. Chemical Composition, Anti-inflammatory and Cytotoxic Activities of Essential Oils from Different Parts of Acanthopanax evodiaefolius. Natural Product Research and Development 27: 1156-1161.
(9) Kim S.G., Kim K.Y., Han C.S., Zhang X.D., and Whang W. K. 2012. Simultaneous analysis of six major compounds in Osteric Radix and Notopterygii Rhizoma et Radix by HPLC and Discrimination of their Origins from Chemical fingerprint analysis[J], Archives of Pharmacal Research, 35(4), 691-699.
(10)刘向前,张晓丹,郑礼胜,周新奇,吴世旭. 黄水枝不同部位挥发性成分的GC-MS研究.现代药物与临床,2010, 1(25): 31-34.
(11)张晓丹,刘向前,李丽丽,金钟焕. 黄水枝化学成分研究. 中草药, 2009, 12(40): 1886-1888.(12)倪娜,刘向前,张晓丹. 8 种五加属植物根皮中五加酸和贝壳烯酸的RP-HPLC 法定量研究.中南大学学报(自然科学版),2009, 5(40): 1216-1221.
(13) 刘向前,李尚玟,李钟泌,张晓丹等. 荆芥不同部位挥发油成分研究. 中草药,2008, 10(39): 1472-1473.
(14) 刘向前,张晓丹等. 曼地亚红豆杉双黄酮结构表征和Taxol定量.中药材,2008, 10(31): 1498-1501.
(15) 闵江,刘向前,张晓丹. RP-HPLC法测定湖南产藤黄科植物元宝草中金丝桃苷的含量, 西北药学杂志, 2007, 22(5): 241-242.
(16) 张晓丹,刘向前,姚金鹏. 半仿生提取法研究中药复方银翘散的浸出率. 中成药, 2007, 29(12): 1771-1774.
三、专利:
1.一种白簕叶片中总多酚分离纯化工艺(201710564656X);
2.一种白簕叶总多酚的超声细胞破碎提取工艺(201710564668.2);
3.一种用于白簕中总多酚纯化的大孔树脂的制备方法(201710564644.7);
4. 白簕叶总多酚的用途(201811166127.5);
5. 树舌灵芝乙醇提取物及其用途(201811166127.5)。