我的研究成果

科研项目：

奶山羊良种扩繁和高效生态养殖技术研究与示范, 浙江省公益性技术应用研究计划项目，2016C32061，2016.01-2017.12，主持

LXRA和PPARG协同调控山羊乳腺不饱和脂肪酸合成研究，国家自然科学基金，31702090，201801-2020.12，主持。

       PPARG对山羊乳腺脂肪酸代谢调控的机制研究，浙江理工大学科研启动项目，2015.7-2018.7，主持。

论文专著：

1)     Hengbo Shi*, Y. Du, C. H. Zhang, C. Sun, Y. L. He, Y. H. Wu, J. X. Liu, J. Luo and J. J. Loor* Fatty acid elongase 5 (ELOVL5) alters the synthesis of long-chain unsaturated fatty acids in goat mammary epithelial cells. Journal of Dairy Science. 2018. (online doi: 10.3168/jds.2017-14061.)

2)     Hengbo Shi, C. H. Zhang, Z. A. Xu, G. G. Lou, J. X. Liu, J. Luo* and J. J. Loor*. Peroxisome proliferator activated receptor delta regulates lipid droplet formation and transport in goat mammary epithelial cells. Journal of Dairy Science. 2018. 101(3):2641-2649

3)     Hengbo Shi#, C. H. Zhang#, Z. A. Xu, X. F. Xu, Z. B. Lv, J. Luo* and J. J. Loor*. Nuclear receptor subfamily 1 group H member 2 (LXRB) is the predominant liver-X-receptor subtype regulating transcription of two major lipogenic genes in goat primary mammary epithelial cells, Journal of Dairy Science, 2017.100(8): 6743–6752

4)     Hengbo Shi., M. Wu, J. J. Zhu, C. H. Zhang, D. W. Yao, J. Luo* and J. J. Loor*. Fatty acid elongase 6 plays a role in the synthesis of long-chain fatty acids in goat mammary epithelial cells. Journal of Dairy Science. 2017.100(1): 797-806

5)     Hengbo Shi, C. H. Zhang, W. Zhao, J. Luo* and J. J. Loor*. 2017. Peroxisome proliferator-activated receptor delta facilitates lipid secretion and catabolism of fatty acids in dairy goat mammary epithelial cells. Journal of Dairy Science. 2017. 100(1):797-806.

6)     Hengbo Shi, W. Zhao, C. Zhang, K. Shahzad, J. Luo* and J. J. Loor*. Transcriptome-Wide Analysis Reveals the Role of PPARG Controlling the Lipid Metabolism in Goat Mammary Epithelial Cells. PPAR Research 2016 : 9195680

7)     Hengbo Shi, K. Yu, J. Luo*, J. Li, H. B. Tian, J. J. Zhu, Y. T. Sun, D. W. Yao, H. F. Xu, H. P. Shi, and J. J. Loor*. Adipocyte differentiation-related protein promotes lipid accumulation in goat mammary epithelial cells. Journal of dairy science.2015, 98(10):6954–6964.

8)     Hengbo Shi, J. Zhu, J. Luo*, H. Shi, D. Yao, J. Li, Y. Sun, Juan. J. Loor*. Genes regulating lipid and protein metabolism are highly expressed in mammary gland of lactating dairy goats. Functional & Integrative Genomics. 2015, 15(3):309-321

9)     Kang Yu#, Hengbo Shi#, J. Luo*, J. Li, H. Tian, H. Shi. PPARG mediates lipid accumulation in dairy GMEC via the regulation of ADRP gene. Journal of Cellular Biochemistry. 2015, 116(1):192-201.

10)  Hengbo Shi, W.S. Zhao, J. Luo*, D.W. Yao, Y. T. Sun, J. Li, H.P. Shi and J. J. Loor*. Peroxisome proliferator-activated receptor-γ1 and -γ2 isoforms alter lipogenic gene networks in goat mammary epithelial cells to different extents. Journal of dairy science. 2014, 97(9): 5437-5447

11)  Huaiping Shi#, Henbo Shi#, Jun Luo*, Wei Wang, Abiel Berhane Haile, Huifen Xu, Jun Li. Establishment and Characterization of a dairy goat mammary epithelial cell line with human telomerase (hT-MECs). Animal Science Journal, 2014, 85: 735–743.

12)  Hengbo Shi, J. Luo*, D. Yao, J. Zhu, H., Xu, H., Shi and J. J. Loor*. Peroxisome proliferator-activated receptor gamma stimulates the synthesis of monounsaturated fatty acids in dairy goat mammary epithelial cells via the control of stearoyl-CoA desaturase. Journal of dairy science. 2013, 96(12):7844-7853.

13)  Hengbo Shi, J. Luo, J*. Zhu, J. Li, Y. Sun, X. Lin, L. Zhang, D. Yao and H. Shi. PPARγ Regulates Genes Involved in Triacylglycerol Synthesis and Secretion in Mammary Gland Epithelial Cells of Dairy Goats. PPAR Research, 2013: 310948.

14)  Yao, D., J. Luo, Q. He, Hengbo Shi, J. Li, H. Wang, H. Xu, Z. Chen, Y. Yi, and J. J. Loor. 2017, SCD1 Alters Long-Chain Fatty Acid (LCFA) Composition and Its Expression Is Directly Regulated by SREBP-1 and PPARgamma 1 in Dairy Goat Mammary Cells. Journal of Cellular Physiology. 232(3): 635-649