我的研究成果

主持项目：

1. 抗血管生成抑制乳腺癌生长转移的作用机制及其靶向抑制剂研究，国家自然科学基金，40 万元，2019.01.01-2021.12.31，主持

2.肿瘤靶标蛋白 TNIK 磷酸化促乳腺 癌生长转移机制及靶向抑制剂研究, 国家自然科学基金, 20.5 万元，2017.01.01-2019.12.31，主持

3. 基于Wnt/β-catenin 通路探讨药根碱靶向 TNIK 抑制结肠癌增殖和转移的作用机制，浙江省自然科学基金，5.0 万元，2016.01.01-2018.12.31，主持

4. 浙江三叶青生产关键技术研究及其示范应用，杭州市科技管理局，10.0万元，2017.01.01-2018.12.31，主持

5. 林下珍稀名贵药材-三叶青新品种选育研究，浙江万里学院，5.0 万元，2016.01.01-2020.12.31，主持

6. 铁皮石斛可食用唇膏口红研发，浙江黛诗堂科技有限公司，5.0 万元，2017.10.27-2017.12.27，主持

   7.靶向Wnt信号通路的天然异喹啉生物碱抑制乳腺癌干细胞侵袭迁移作用机制，浙江省药学重中之重一级学科-温州医科大学开放基金，6.0 万元，2017.05.23- 2017.12.31，主持

发表论文：

1. Xiaodan Zhang^#, Yange Yu^#, Dongfeng Yang, Zhechen Qi, Ruizhen Liu, Fengtao Deng, Zengxuan Cai, Ying Li, Yanfang Sun*, Zongsuo Liang*. Chemotaxonomic variation in seconary metabolites contents and their correlation between environmental factors in Salvia miltiorrhiza Bunge from natural habitat of China. Industrial Crops & Products 113 (2018) 335-347. (SCI, IF=3.181)

2. Yanfang Sun, Michael Wink, Pan Wang, Zongsuo Liang*. Biological characteristics, bioactive components and antineoplastic properties of sporoderm-broken spores from wild Cordyceps cicadae. Phytomedicine 36 (2017) 217-228. (SCI, IF=3.526)

3. Yanfang Sun, Pingping Wu, Yang Sun, Zongsuo Liang*. Lycorine possesses notable anticancer potentials in non-small cell lung carcinoma cells via blocking Wnt/β-catenin signalling and epithelial-mesenchymal transition (EMT). Biochemical and Biophysical Research Communications 495 (2018) 911-921. (SCI, IF=2.466)

4. Wenwen Xu^#, Yanfang Sun^#, Xiaoping Dong, Huigang Wang*. Local order and vibrational coupling of the C=O stretching mode of γ-Caprolactone in liquid binary mixtures. Scientific Reports 7（2017）12182. (SCI, IF=4.259)

5. Yanfang Sun, Zhangqi Wang, Boqi Li, Zongsuo Liang*. Biological characteristics of Edgeworthia tomentosa (Thunb.) Nakai flowers and antimicrobial properties of their essential oils. Natural Product Research, 2017. (SCI, IF=1.828)

6. Yanfang Sun, Wan Wang, Juanfang Xie, Zongsuo Liang*. Biological characteristics and germination conditions of Gentianae macrophylla seeds under different storage and seed treatments. International Journal of Agriculture & Biology 19 (2017) 502-508. (SCI, IF=0.746)

7. Yanfang Sun, Yang Sun, Zongsuo Liang*. Isaria cicadae conidia possess antiproliferative and inducing apoptosis properties in gynecological carcinoma cells. Mycology, 2017.

8. Yanfang Sun*, Michael Wink*. Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells. Phytomedicine 21 (2014)1110-1119. (SCI, IF=3.526)

9. Yanfang Sun, Chuankui Song, Helmut Viernstein, Frank Unger, Zongsuo Liang*. Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway. Food Chemistry 138 (2013)1998-2007. (SCI, IF=4.529)

10. Yanfang Sun, Zongsuo Liang*, Changjuan Shan, Helmut Viernstein, Frank Unger. Comprehensive evaluation of natural antioxidants and antioxidant potentials in Ziziphus jujube Mill. var spinose (Bunge) Hu ex H. F. Chou fruits based on geographical origin by TOPSIS method. Food Chemistry 124 (2011)1612-1619. (SCI, IF=4.529)

专利：金蝉花美白保湿药妆品及其制备方法 （授权号：ZL 2016 l 0082170.8）

 获奖情况：

1. 2009年获得奥地利联邦政府“欧亚太平洋”博士奖学金

2. 2012-2013年获得德国联邦政府DAAD博士后奖学金和国家留学基金委博士后奖学金

3. 2015年荣获首届星耀南湖嘉兴海外创新创业大赛总决赛优胜奖

4. 2016年科研工作先进个人，优秀学生寝室成长导师，本科生优秀毕业论文指导教师

5. 2017年优秀班主任

6. 2017年荣获天士力控股集团第九届产品研发、技术创新研讨会“优秀论文奖”