研究成果
五、承担课题：
主持和主要参与的国内外研究项目：
1）国家863计划海洋生物资源利用技术领域课题“饲料用海洋脂肪酶-单细胞蛋白联产关键技术及产品”经费：189万元，项目编号：2014AA093510（主持，2014/01-2016/12）
2）国家自然科学基金医学部海洋药物面上项目“基于Keap1-Nrf2-ARE信号通路的活性先导化合物的发现及作用机制研究”经费：60万元，项目编号：81373321（主持，2014/01-2017/12）
3）国家863计划课题“深海微生物分离培养与基因资源获取技术研究”经费：20万元，项目编号：2012AA092103（骨干，2012/01-2015/12）
4）浙江省自然科学基金“浙江近海半丰满鞘丝藻的抗癌活性物质筛选、分离及结构分析”，（Y2100044）（主持, 2010-2012）
5）浙江大学科研青年专项“浙江近海海洋蓝藻的抗癌活性物质筛选、分离及结构分析”（2010QNA4014）（主持，2010-2012）
6）项目：Mitochondrial Proteomics of the Aging Heart（2007）
资助: 美国国立卫生研究院（NIH）重大项目; 5R01AG025372-03（主要参与）
7）项目：Neurotoxins from Marine Algae and Cyanobacteria（2007）
资助: 美国国立卫生研究院（NIH）重大项目; 5R01NS053398-07 （主要参与）
8）项目：Lipidomic profile of endocannabinoids from neuronal cells（2011）
资助: 美国国立卫生研究院（NIH）项目; R21 DA024193 （主要参与）
六、发表论文（代表性）：
1. Qiu-Ye Chai, Zhen Yang, Hou-Wen Lin,* and Bing-Nan Han*. Alkynyl-Containing Peptides of Marine Origin: A Review Mar. Drugs 2016, 14, 216; doi:10.3390
2. Jian-Hong Gan, Wen-Zhen Hu, Hao-Bing Yu, Fan-Yang, Meng-Xue Cao, Hua-Jin Shi, Yong-Feng Kang* and Bing-Nan Han*. Three New Aaptamine Derivatives from the South China Sea Sponge Aaptos aaptos. J. Asian Natural Products Research; 2015 17(12), 1231-1238
3. Kai-Xuan Zhan, Wei-Hua Jiao, Fan Yang, Jing Li, Shu-Ping Wang, Yu-Shan Li,Bing-Nan Han,*（共同通讯） and Hou-Wen Lin *. Reniochalistatins A–E, Cyclic Peptides from the Marine Sponge Reniochalina stalagmitis. J. Nat. Prod. ; 2014, 77 (12), pp 2678–2684
4. Shu-Juan Piao, Wei-Hua Jiao, Fan Yang, Yang-Hua Yi, Ying-Tong Di, Bing-Nan Han,*（共同通讯） and Hou-Wen Lin *. New Hippolide Derivatives, withProtein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity from the Marine Sponge Hippospongia lachne. Mar. Drugs; 2014, 12(7), 4096-4109
5. Shu-Juan Piao,Yun-Long Song,Wei-Hua Jiao,Fan Yang,§ Xiang-Fang Liu, Wan-Sheng Chen, Bing-Nan Han*（共同通讯）, and Hou-Wen Lin*. Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne.Org. Lett.；15 (14), 3526–3529，2013
6. Bingnan Han*, Rachel Wright, Yi Fang, Aaron Kirchoff, Vincent jo Davisson, Julia Chester and Eric Barker . Quantitative LC–MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. Analytical Biochemistry; 432(2),74-81，2013
7. Bingnan Han, Mike Hare and Claudia S. Maier. A differential “Bottom Up” proteomic strategy for the
site-specific identification and quantitation of endogenous oxylipid protein modifications. Journal of proteomics ；75(18)，5724-5733, 2012
8. Bingnan Han, Luke H. Stockwin, Chad Hancock, Sherry X. Yu, Melinda G. Hollingshead, and Dianne L. Newton. Proteomic Analysis of Nuclei isolated from cancer cell lines treated with Indenoisoquinoline NSC724998, a novel Top1 inhibitor. Journal of Proteome Research; 9(8), 4016-4027, 2010
9. Bingnan Han*, Harald Gross, Kerry L. McPhail, Doug Goeger, Claudia S. Maier,William H. Gerwick. Wewakamide A and guineamide G, cyclic depsipeptides from the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula. Journal of Microbiology and Biotechnology(IF: 1.4); 21(9)，930-936, 2012
10. Bingnan Han, Uwe M. Reinscheid, William H. Gerwick, Harald Gross. The structure elucidation of isomalyngamide K from the marine cyanobacterium Lyngbya majuscula by experimental and DFT computational methods. Journal of Molecular structure(IF: 1.7); 989, 109-113, 2011
11. Chad N. Hancock,Luke H. Stockwin, Bingnan Han, Raymond D. Divelbiss, Jung Ho Jun, Sajay V Malhotra, Melinda G. Hollingshead and Dianne L. Newton. A copper chelate of thiosemicarbazone NSC689534 induces Oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radical Biology and Medicine(IF: 5.8); 50(1)，110-21, 2011
12. Saini V, Hose CD, Monks A, Nagashima K, Han B, Newton DL, Millione A, Shah J, Hollingshead MG, Hite KM, Burkett MW, Delosh RM, Silvers TE, Scudiero DA, Shoemaker RH. Identification of CBX3 and ABCA5 as Putative Biomarkers for Tumor Stem Cells in Osteosarcoma. PLoS One(IF: 4.1); 7(8)，e41401, 2012
13. Luke H. Stockwin, Bingnan Han, Maja A. Bumke, Sherry X. Yu, Melinda G. Hollingshead, Mahmoud A. ElSohly, Waseem Gul, Desmond Slade, Ahmed Galal, and Dianne L. Newton. Artemisinin dimeranti-cancer activity is mediated by heme-catalyzed ROS generation and ER stress Induction.International Journal of Cancer(IF: 5.4); 125(6), 1266-1275, 2009
14. Bingnan Han, Fred Stevens and Claudia S. Maier. Design, Synthesis, and Application of a Hydrazide-Functionalized Isotope-Coded Affinity Tag (HICAT) for the Quantification of Oxylid Protein Conjugates. Anal. Chem.(IF: 5.8); 2007; 79(9); 3342-3354.
15. Juan Chavez, Jianyong Wu, Bingnan Han, Woon-Gye Chung, and Claudia S. Maier. New Role for an Old Probe: Affinity Labeling of Oxylipid Protein Conjugates by N’-Aminooxymethylcarbonylhydrdrazino-D-biotin. Anal. Chem.78 (19), 6847 -6854, 2006.
16. Ramaswamy AV, Flatt PM, Edwards DJ, Simmons TL, Han B and Gerwick WH. The secondary metabolites and biosynthetic geneclusters of marine cyanobacteria. Applications in biotechnology. Frontiers in Marine Biotechnology (2006), 175-224.
17. Bingnan Han, Harald Gross, Douglas E. Goeger, Susan L. Mooberry, and William H. Gerwick. Aurilides B and C, Cancer Cell Toxins from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscule. J. Nat. Prod. 2006, 69, 572-575.
18. 15．Bingnan Han, Kerry L. McPhail, Harald Gross, Doug Goeger, Susan Mooberry, and William H. Gerwick. Isolation and Structure of Five Lyngbyabellin Derivatives from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscule. Tetrahedron, 2005, 61, 11723-11729.
19. Bingnan Han, Doug Goeger, Claudia S. Maier, and William H. Gerwick. The Wewakpeptins, Cyclic Depsipeptides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbyasemiplena. J. Org. Chem. , 2005, 70 (8), 3133
20. Bingnan Han, Kerry L. McPhail, Alessia Ligresti, Vincenzo Di Marzo, and William H. Gerwick. Semiplenamides A-G, Fatty Acid Amides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngabya semiplena. J. Nat. Prod., 2003, 66, 1364-1368.
21. Hao-Bing Yu, Yang Fan, Sun Fan, Guo-Yi Ma, Jian-Hong Gan, Wen-Zhen Hu, Bing-Nan Han, Wei-Hua Jiao, and Hou-Wen Lin. Cytotoxic aaptamine derivatives from the South China Sea sponge Aaptos aaptos.Journal of Natural Products, 77(9), pp 2124-2129, 2014/9/26.
22. Yang Fan, Yike Zou, Ru-Ping Wang, Hamann Mark T, Hong-Jun Zhang, Wei-Hua Jiao, Bing-Nan Han, Shao-Jiang Song, and Hou-Wen Lin. Relative and absolute stereochemistry ofdiacarperoxides: antimalarial norditerpene endoperoxides from marine sponge Diacarnus megaspinorhabdosa.Marine Drugs, 12(8), pp 4399-4416, 2014/8.
23. Wei-Hua Jiao, Ting-Ting Xu, Hao-Bing Yu, Guo-Dong Chen, Xiao-Jun Huang, Yang Fan, Yu-Shan Li, Bing-Nan Han, Xiao-Yan Liu, and Hou-Wen Lin. Dysideanones A-C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysidea avara. Journal of Natural Products, 77(2), pp 346-350, 2014/2.
24. Wei-Hua Jiao, Ting-Ting Xu, Hao-Bing Yu, Feng-Rong Mu, Jia Li, Yu-Shan Li, Fan Yang, Bing-Nan Han, and Hou-Wen Lin. Dysidaminones A–M, cytotoxic and NF-kB inhibitory sesquiterpene aminoquinones from the South China Sea sponge Dysidea fragilis.RSC Advances, 4(18), pp 9236-9246, 2014/1/20.
25. Wei-Hua Jiao, Li Jing, Liu Qian, Ting-Ting Xu, Guo-Hua Shi, Hao-Bing Yu, Yang Fan, Bing-Nan Han, Li Min, and Hou-Wen Lin. Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp.Molecules, 19(11), pp 18025-18032, 2014.
26. Yan Min, Zhu Yan, Hong-Jun Zhang, Wei-Hua Jiao, Bing-Nan Han, Zhao-Xi Liu, Qiu Feng, Wan-Sheng Chen, and Hou-Wen Lin. Anti-inflammatory secondary metabolites from the leaves of Rosa laevigata. BIOORGANIC & MEDICINAL CHEMISTRY, 21(11), pp 3290-3297, 2013
