研究成果
一、科研获奖
1. 姚菊明，冯新星，陈文兴，孔祥东，姚玉元，张华鹏，郭玉海，桑蚕丝素蛋白结构基础上的功能化研究，浙江省人民政府，2007年度浙江省科学技术二等奖（主要完成人）
2. 崔福斋，王秀梅，李恒德，蔡强，孔祥东，生物矿化纤维的分级组装机理研究，中华人民共和国国务院，2011年度国家自然科学奖二等奖（主要完成人）
3. 崔福斋，王秀梅，李恒德，蔡强，孔祥东，生物矿化纤维的分级组装机理研究，北京市人民政府，2010年度北京市科学技术奖二等奖（主要完成人）
4. 孔祥东，姚菊明，董何彦，王玮，刘琳，蔡玉荣，余厚咏，李昕跃，杨刚，周旭晨，医用金属基生物材料的表面生物活化及载药功能化的关键技术，2013年度中冶集团科技进步奖二等奖（第一完成人）
5. 朱良均, 姚菊明, 杨明英, 孔祥东, 沈新琦, 徐国文, 闵思佳, 张海萍, 刘琳, 邓连霞, 朱正华, 帅亚俊, 许宗溥，蚕丝蛋白增值关键技术、产业化生产及其功能化应用研究，2015年度浙江省科技进步一等奖（主要完成人）
6. 朱良均, 姚菊明, 杨明英, 孔祥东, 沈新琦, 徐国文, 闵思佳, 张海萍, 刘琳, 邓连霞, 朱正华, 帅亚俊, 许宗溥，蚕丝蛋白制备关键技术及其高值化利用研究，2015年度中国纺织工业联合会科学技术二等奖（主要完成人）
二、发表的学术论文
1. XD Kong, FZ Cui, XM Wang, M Zhang, W Zhang, Silk fibroin regulated mineralization of hydroxyapatite nanocrystals, Journal of Crystal Growth, 2004, 270(1-2): 197-202
2. XD Kong, XM Wang, X Yu, FZ Cui, Preparation of Hydroxyapatite-fibroin Nanocomposites, Key Engineering Materials, 2005, 288-289: 191-194
3. XD Kong, XD Sun, JB Lu, FZ Cui, Mineralization of calcium phosphate in Reverse microemulsion, Current Applied Physics, 2005, 5(5): 519-521
4. XD Kong, XD Sun, FZ Cui, C Ma, Effect of solute concentration on fibroin regulated biomineralization of calcium phosphate, Materials Science and Engineering C, 2006, 26(4): 639-643
5. XD Sun, XD Kong, YD Wang, et al. Formation of manganite fibers under the directing of cationic surfactant, Materials Science and Engineering C, 2006, 26: 653-656
6. Y Wang, FZ Cui, Y Zhai, XM Wang, XD Kong, Investigations of the initial stage of recombinant human-like collagen mineralization, Materials Science and Engineering C, 2006，26（4）635-638
7. K Hu, Q Lv, FZ Cui, QL Feng，XD Kong, Biocompatible Fibroin Blended Films with Recombinant Human-like Collagen for Hepatic Tissue Engineering, Journal of Bioactive and Compatible Polymers, 2006, 21: 23-37
8. YJ Ren, Sun XD, Cui FZ, Wei YT, Cheng ZJ, XD Kong , Preparation and characterization of Antheraea pernyi silk fibroin based nano-hydroxyapatite composites, Journal of Bioactive and Compatible Polymers, 2007, 22:465-474
9. JL Zhan, XD Sun, FZ Cui, XD Kong, Preparation of 3-d porous fibiroin scaffolds by freeze drying with treatment of methanol solutions. Chin. Sci. Bull. 2007, 52:1791-1795
10. YJ Ren, Sun XD, FZ Cui, XD Kong, Effects of pH and initial Ca2+-H2PO4- concentration on fibroin mineralization, Frontiers of Materials Science in China，2007, 1: 258-262
11. XD Kong，XD Sun, M Qiu, RS Xie, A novel method to prepare mineralized fibroin fiber. Frontiers of Materials Science in China，2007, 1: 243-246
12. 姚菊明，魏克民，励丽，孔祥东，祝永强，林凤，桑蚕丝素蛋白初始结构对其矿化作用的影响，化学学报，2007，65（7）：635-639
13. L Li, KM Wei, F Lin, XD Kong, JM Yao, Effect of silicon on the formation of silk fibroin/calcium phosphate composite, Journal of Materials Science-Materials in Medicine, 2007, 65: 635-639
14. 刘琳，孔祥东，蔡玉荣，姚菊明，纳米羟基磷灰石/丝素蛋白复合支架材料的降解特性及生物相容性研究，化学学报，2008，66（16）：1919-1923
15. Yucheng Li, Yurong Cai, Xiangdong Kong, Juming Yao, Anisotropic growth of hydroxyapatite on the silk fibroin films, Applied Surface Science , 2008, 255: 1681–1685
16. Chunling Du, Jun Jin, Yucheng Li, Xiangdong Kong, Kemin Wei, Juming Yao, Novel silk fibroin/hydroxyapatite composite films: Structure and properties, Materials Science and Engineering C, 2009, 29: 62–68
17. 刘琳，孔祥东，李玉成，蔡玉荣，姚菊明，预处理对丝素蛋白膜调控羟基磷灰石晶体生长的影响，高等学校化学学报，2009，30（10）：1987-1991
18. Lin Liu, Jinying Liu, Xiangdong Kong, Yurong Cai, Juming Yao, Porous composite scaffolds of hydroxyapatite/silk fibroin via two-step method, Polymers for Advanced Technologies 2011, 22:909-914
19. Mingli Pan, Xiangdong Kong, Yurong Cai, Juming Yao. Hydroxyapatite coating on the titanium substrate modulated by a recombinant collagen-like protein. Materials Chemistry and Physics 2011, 126:811-817
20. Xiangdong Kong*, Suju Xu, Xiumei Wang, Fuzhai Cui, Juming Yao. Calcium carbonate microparticles used as a gene vector for delivering p53 gene into cancer cells. Journal of Biomedical Materials Research Part A，2012，100A(9):2312-2318
21. Chang Gao, Yurong Cai, Xiangdong Kong, Guoxiang Han, Juming Yao, Development and characterization of injectable chitosan-based hydrogels containing dexamethasone/rhBMP-2 loaded hydroxyapatite nanoparticles. Materials Letters. 2013, 93:312-315
22. Suju Xu, Fuzhai Cui, Xiaolong Yu, Xiangdong Kong*, Glioma cell line proliferation controlled by different chemical functional groups in vitro, Frontiers of Materials Science, 2013, 7(1) 69-75
23. Ruibo Zhao, Huafeng Han, Shao Ding, Zehao Li, Xiangdong Kong.* Effect of silk sericin on morphology and structure of calcium carbonate crystal. Frontiers of Materials Science 2013, 7(2) :177-183
24. Ruibo Zhao, Xinyan Yang, Cen Chen, Kan Chen, Shibing Wang, Chungang Xie, Xiaoyuan Ren, Xiangdong Kong*, The anti-tumor effect of p53 gene-loaded hydroxyapatite nanoparticles in vitro and in vivo, Journal of Nanoparticle Research, 2014, 16(4), Article Number: 2353, DOI: 10.1007/s11051-014-2353-y
25. Suju Xu, Fuzhai Cui, and Xiangdong Kong*, Tumor-suppressor effects of chemical functional groups in an in vitro co-culture system, Frontiers of Materials Science, 2014, 8(2):136-141
26. Cen Chen, Wei Yang, Dantong Wang, Chaolong Chen, Qingye Zhuang, Xiangdong Kong*. A modified spontaneous emulsification solvent diffusion method for the preparation of curcumin-loaded PLGA nanoparticles with enhanced in vitro anti-tumor activity, Frontiers of Materials Science, 2014, 8(4): 332-342
27. Kan Chen, Qiuwei Pan, Ying Gao, Xinyan Yang, Shibing Wang, Maikel P. Pepplenbosch, Xiangdong Kong*. DMS triggers apoptosis associated with the inhibition of SPHK1/NF-κB activation and increase in intracellular Ca2+ concentration in human cancer cells. International Journal of Molecular Medicine, 2014, 33: 17-24
28. Tao Liu, Xinbo Ding, Dongzhi Lai, Yongwei Chen, Ridong Zhang, Jianyong Chen, Xinxing Feng, Xiaoyi Chen, Xianyan Yang, Ruibo Zhao, Kai Chen, Xiangdong Kong, Enhancing in vitro bioactivity and in vivo osteogenesis of organic-inorganic nanofibrous biocomposites with novel bioceramics, Journal of Materials Chemistry B, 2014, 2(37): 6293-6305
29. Zhaogang Liu , Yurong Cai , Yaru Jia , Lin Liu , Xiangdong Kong, Subhas C. Kundu , Juming Yao, One-Step Synthesis of Natural Silk Sericin-Based Microcapsules with Bionic Structures. Macromolecular Rapid Communications, 2014, 35(19): 1668-1672, DOI: 10.1002/marc.201400304
30. Cen Chen, Xiangdong Kong, Shengmin Zhang, In-Seop Lee, Characterization and in vitro Evaluation of Mineral/Osteogenic Growth Peptide Nano Composites Synthesized Biomimetically on Titanium. Applied Surface Science，2015, 334: 62-68
31. Cen Chen, Shengmin Zhang, Han Li, Xiangdong Kong, In-Seop Lee，Immobilizing osteogenic growth peptide with and without fibronectin onto titanium surface: effects of loading methods on mesenchymal stem cells differentiation, International Journal of Nanomedicine，2015, 10: 283-295, DOI: 10.2147/IJN.S74746
32. Guohua Jiang, Tengteng Jiang, Huijie Zhou, Juming Yao, Xiangdong Kong, Preparation of N-doped carbon quantum dots for highly sensitive detection of dopamine by an electrochemical method, RSC Advances, 2015, 5(12):9064-9068
33. Tengteng Jiang, Guohua Jiang, Lei Li, Hua Chen, Huijie Zhou, Juming Yao, Xiangdong Kong, Wenxing Chen, N-Doped carbon hybrid conjugates as vectors for photocatalytic CS2 production. Materials Research Express, 2015, 2(4):045603
34. Lei Li, Guohua Jiang , Xiangxiang Du, Hua Chen, Yongkun Liu, Qin Huang, Xiangdong Kong, Juming Yao, Preparation of glucose-responsive and fluorescent micelles via a combination of RAFT polymerization and chemoenzymatic transesterification for controlled release of insulin. RSC Advances, 2015, 5(92): 75766-75772
35. K Chen , W Cao , J Li , D Sprengers , PY Hernanda , X Kong , LJ Van Der Laan, K Man , J Kwekkeboom, HJ Metselaar , MP Peppelenbosch , Q Pan , Differential Sensitivities of Fast- and Slow-cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by Mycophenolic Acid. Molecular Medicine, 2015, 21:792-802
36. Suju Xu, Zhiye Qiu, Jingjing Wu, Xiangdong Kong, Xisheng Weng, Fuzhai Cui*, Xiumei Wang*, Osteogenic differentiation gene expression profiling of hMSCs on hydroxyapatite and mineralized collagen. Tissue Engineering Part A, 2016, 22(1-2): 170-181
37. Wen Lai, Cen Chen, Xiaoyuan Ren, In-Seop Lee, Guohua Jiang, Xiangdong Kong*, Hydrothermal fabrication of porous hollow hydroxyapatite microspheres for a drug delivery system, Materials Science and Engineering C, 2016, 62: 166-172
38. Wei Yang, Chenxue Yao, Zhengyang Cui, Dandan Luo, In-Seop Lee, Juming Yao, Cen Chen, Xiangdong Kong*, Poly (acrylic acid) regulated synthesis of rod-like calcium carbonate nanoparticles for inducing the osteogenic differentiation of MC3T3-E1 cells, International Journal of Molecular Sciences, 2016, 17(5): Article Number: 639
39. Cen Chen, Huafeng Han, Wei Yang, Xiaoyuan Ren, Xiangdong Kong*，Polyethyleneimine-modified calcium carbonate nanoparticles for p53 gene delivery, Regenerative Biomaterials, 2016, 3(1):57-63
40. Xiaochun Xu, Zehao Li, Xueqin Zhao, Lawrence Keen, Xiangdong Kong* , Calcium phosphate nanoparticles based systems for siRNA delivery, Regenerative Biomaterials, 2016, 3(3): 189-195
41. Cen Chen, Xiangdong Kong, In-Seop Lee*. Modification of surface/neuron interfaces for neural cell-type specific responses: a review. Biomedical Materials, 2016, 11: 014108, doi:10.1088/1748-6041/11/1/014108
42. Lei Li, Guohua Jiang, Weijiang Yu, Depeng Liu, Hua Chen, Yongkun Liu, Qin Huang, Zaizai Tong, Juming Yao, Xiangdong Kong, A composite hydrogel system containing glucose-responsive nanocarriers for oral delivery of insulin, Materials Science and Engineering C, 2016, 69: 37-45
43. Depeng Liu, Guohua Jiang, Weijiang Yu, Lei Li, Zaizai Tong, Xiangdong Kong, Juming Yao, Oral delivery of insulin using CaCO3-based composite nanocarriers with hyaluronic acid coatings. Materials Letters, 2017, 188: 263-266
44. Weijiang Yu, Guohua Jiang, Depeng Liu, Lei Li, Hua Chen, Qin Huang, Zaizai Tong, Juming Yao, Xiangdong Kong. Fabrication of biodegradable composite microneedles based on calcium sulfate and gelatin for transdermal delivery of insulin. 2016, Materials Science and Engineering C, 2017, 71:725-734
45. Lei Li, Guohua Jiang, Weijiang Yu, Depeng Liu, Hua Chen, Yongkun Liu, Zaizai Tong, Xiangdong Kong, Juming Yao, Preparation of chitosan-based multifunctional nanocarriers overcoming multiple barriers for oral delivery of insulin. Materials Science and Engineering C. 2017, 70: 278-286
46. Yurong Cai, Junmao Guo, Cen Chen, Chenxue Yao, Sung-Min Chung, Juming Yao, In-Seop Lee, Xiangdong Kong*. Silk fibroin membrane used for guided bone tissue regeneration, Materials Science and Engineering C, 2017, 70: 148-154
47. Ruibo Zhao, Xiaoyuan Ren, Chungang Xie, Xiangdong Kong*, Towards understanding the distribution and tumor targeting of spherical calcium phosphate nanoparticles, Microscopy Research and Technique, 2016, Accepted
48. 李战春，俞兴，孔祥东， 矿化丝基骨材料的制备和生物相容性及体内降解的观察，生物骨科材料与临床研究，2005. 2（2）：1-3
49. 丁少，王海龙，须苏菊，孔祥东*, 丝胶对碳酸钙晶体生长的调控作用研究, 丝绸，2012，49（6）：8-11
50. 须苏菊，孔祥东*，赵瑞波，韩华锋，新型基因治疗载体——纳米羟基磷灰石，材料科学，2013，3:11-15
51. 韩华锋，徐阳，孔祥东*，基于纳米碳酸钙的药物缓释载体研究. 纳米技术，2013，3(4)：41-46
52. 王世兵，陈侃，孔祥东*，基于痘苗病毒载体的恶性肿瘤基因治疗研究进展，中国细胞生物学学报，2014，36(1): 1-8
53. 张瑾丽，任小元，张祺，孔祥东*, 仿生矿化法制备HA/SF/Ti复合材料的研究进展，丝绸，2014，51(3):19-24
54. 张瑾莉，张祺，解纯刚，任小元，孔祥东*, 丝素蛋白膜调控钛表面磷酸钙晶体生长的研究，蚕业科学，2014，40(4):706-711
55. 李泽豪，任小元，王世兵，孔祥东*，介导siRNA传递的非病毒载体及其研究进展，生命科学，2014，26(4):392-399
56. 韩华锋，杨卫，陈菲菲，李泽豪，孔祥东*，碳酸钙微球合成、修饰及作为基因载体的研究，浙江理工大学学报（自然科学版），2014，31(6):685-690
57. 赵瑞波，杨新燕，韩华锋，解纯刚，孔祥东*，基于纳米羟基磷灰石基因载体转染效率及靶向性的研究进展，材料导报，2014，28（5）：124-128
58. 赖文，陈岑，叶婷，章赛赛，吕晓露，孔祥东*，无齿相手蟹体表刚毛的结构及其功能，浙江理工大学学报（自然科学版），2016，35(5):126-133
59. 钟云平，姚晨雪，赖文，陈岑，解纯刚，孔祥东*，纳米羟基磷灰石携载lefty-1基因对人乳腺癌细胞的杀伤效应，浙江理工大学学报（自然科学版），2016, 35(5): 109-114
60. 宋国龙，赵雪芹，孔祥东*，Ca2+对CdTe量子点复合丝素蛋白凝胶的影响，蚕桑通报，2016，47(1): 16-19
61. 韩义忠，崔正阳，陈岑，叶婷，孔祥东*，以贻贝贝壳为原料制备的无定型磷酸钙及其性质，浙江理工大学学报（自然科学版），2016, 35（6）: 849-854
62. 何欢，董文韬，郑娓诗，孔祥东，陈岑，解纯刚，纳米羟基磷灰石颗粒负载p53基因对肝癌干细胞抑制效果，浙江理工大学学报（自然科学版），2017, 36：167-173
