我的研究成果

承担国家863项目2项、国家科技支撑项目1项。主持浙江省自然科学基金项目、浙江省科技厅项目、浙江省教育厅项目、浙江省生物医学工程“重中之重”开放基金项目各1项。发表论文20余篇，申请国家发明专利3项，已授权1项，获得浙江省自然科学学术二等奖、三等奖各1项，近五年发表SCI论文如下： 

1.   Zhang, W.; Wang, J.; Zhang, C.; Fang, Q.; Shu, J.; Li, S.; Jin, J.; Wang, D.; Nie, Z.; Lv, Z.; Zhang, Y.  Synergetic Protein Factors That Improve rhGM-CSF Absorption via an Oral Route Exist in Silkworm Pupae. Molecular pharmaceutics 2015, 12, (5), 1347-55.

2.   Zhang, W.; Zhang, C.; Lv, Z.; Fang, D.; Wang, D.; Nie, Z.; Yu, W.; Lan, H.; Jiang, C.; Zhang, Y.  Molecular characterization, tissue distribution, subcellular localization and actin-sequestering function of a thymosin protein from silkworm. PLoS One 2012, 7, (2), e31040.

3.   Zhang, W. P.; Lan, H. L.; Wu, T.; Jiang, C. Y.; Lv, Z. B.; Nie, Z. M.; Wu, X. F.; Zhang, Y. Z.  Expression analysis and characteristics of hypothetical protein BmLOC778500 from silkworm, Bombyx mori. Afr J Biotechnol 2011, 10, (19), 3753-3761.

4.   Zhang, W.; Lv, Z.; Nie, Z.; Chen, G.; Chen, J.; Sheng, Q.; Yu, W.; Jin, Y.; Wu, X.; Zhang, Y.  Bioavailability of orally administered rhGM-CSF: a single-dose, randomized, open-label, two-period crossover trial. PloS one 2009, 4, (5), e5353.

5.   张文平; 杨久春; 吕正兵; 陶雷; 张耀洲.  多肽和蛋白质药物口服吸收机制及策略的研究进展. 中国药理学与毒理学杂志 2013, 25, (5), 903-907.

6.   张文平，吕正兵，龙晓辉，聂作明，夏佳音，张耀洲.  家蚕孤雌生殖相关蛋白ＰＧＬ的鉴定与生物信息学分析. 蚕业科学 2010, 36, (6), 889-896.

7.   Nie, Z.; Zhou, F.; Li, D.; Lv, Z.; Chen, J.; Liu, Y.; Shu, J.; Sheng, Q.; Yu, W.; Zhang, W.; Jiang, C.; Yao, Y.; Yao, J.; Jin, Y.; Zhang, Y.  RIP-seq of BmAgo2-associated small RNAs reveal various types of small non-coding RNAs in the silkworm, Bombyx mori. BMC genomics 2013, 14, 661.

8.   Liu, Y.; Chen, Y.; Chen, J.; Zhang, W.; Sheng, Q.; Yu, W.; Nie, Z.; Zhang, Y.; Wu, W.; Wang, L.; Indran, I. R.; Li, J.; Qian, L.; Lv, Z.  A shark liver gene-derived active peptide expressed in the silkworm, Bombyx mori: preliminary studies for oral administration of the recombinant protein. Marine drugs 2013, 11, (5), 1492-505.

9.   Lv, Z.; Wang, T.; Zhuang, W.; Wang, D.; Chen, J.; Nie, Z.; Liu, L.; Zhang, W.; Wang, L.; Wu, X.; Li, J.; Qian, L.; Zhang, Y.  The Expression, Purification, and Characterization of a Ras Oncogene (Bras2) in Silkworm (Bombyx mori). International journal of genomics 2013, 2013, 269609.

10. Lu, C.; Zhang, J.; Nie, Z.; Chen, J.; Zhang, W.; Ren, X.; Yu, W.; Liu, L.; Jiang, C.; Zhang, Y.; Guo, J.; Wu, W.; Shu, J.; Lv, Z.  Study of microRNAs related to the liver regeneration of the whitespotted bamboo shark, Chiloscyllium plagiosum. BioMed research international 2013, 2013, 795676.

11. Zhang, J.; Liu, Y.; Zhang, X.; Pan, J.; Nie, Z.; Zhang, W.; Yu, W.; Chen, J.; Liu, L.; Li, J.; Zhang, Y.; Guo, J.; Wu, W.; Zhu, H.; Lv, Z.  The identification of microRNAs in the whitespotted bamboo shark (Chiloscyllium plagiosum) liver by Illumina sequencing. Gene 2013, 527, (1), 259-65.

12. Lv, Z.; Zhang, X.; Liu, L.; Chen, J.; Nie, Z.; Sheng, Q.; Zhang, W.; Jiang, C.; Yu, W.; Wang, D.; Wu, X.; Zhang, S.; Li, J.; Zhang, Y.  Characterization of a gene encoding prohibitin in silkworm, Bombyx mori. Gene 2012, 502, (2), 118-24.

13. Zhang, Y.; Xia, Q.; Xu, J.; Chen, J.; Nie, Z.; Wang, D.; Zhang, W.; Zheng, Q.; Chen, Q.; Kong, L.; Ren, X.; Wang, J.; Lv, Z.; Yu, W.; Jiang, C.; Liu, L.; Sheng, Q.; Jin, Y.; Wu, X.  Aligning the proteome and genome of the silkworm, Bombyx mori. Functional & integrative genomics 2009, 9, (4), 447-54.