研究成果

共发表学术论文50多篇,其中SCI收录论文20多篇,申请国家发明专利3项。

代表性论文

LF He*, YG Wang*, T Xiao, KJ Zhang, GC Li, JF Gu, L Chu, WH Tang, WS Tan, XY Liu. Suppression of cancer growth in mice by adeno-associated virus vector-mediated IFN-β expression driven by hTERT promoter. Cancer Letters. 2009, 286(2): 196-205. (* as first co-author)

Liu X, Wang Y, Niu H, Zhang X, Tan WS. The improvement of adenovirus vector production by increased expression of coxsackie adenovirus receptor. Biotechnol Lett. 2009, 31(7): 939-44.

Xuping Liu, Liang Zhao, Yigang Wang, Xu Zhang and Wen-Song Tan. Effects of calcium ion on adenovirus production with high densities of HEK293 cells. J Biotechnol. 2010, 15(3): 414-420.

Yigang Wang, Kangjian Zhang, Haibo Cai, Yumei Wu, Guoqing He, Wen-Song Tan. The efficacy of combination therapy using Adeno-associated virus-TRAIL targeting to telomerase activity and cisplatin in a mice model of hepatocellular Carcinoma. J Cancer Res Clin Oncol, 2010, 136(12): 1827-1837.

谢宏霞, 曾凤辉, 刘鸿, 蒋海, 王毅刚*. 磷酸化和乙酰化修饰对STAT3功能的调节. 中国细胞生物学学报. 2010, 32(1): 115-120.

Xiao L, Li X, Niu N, Qian J, Xie G, Wang Y*. Dichloroacetate (DCA) enhances tumor cell death in combination with oncolytic adenovirus armed with MDA-7/IL-24. Mol Cell Biochem. 2010, 340(1-2): 31-40.

Yigang Wang, Lingfeng He, Guoqing He, Yanping Kong, Xuping Liu, Haibo Cai, Xinyuan Liu and Wensong Tan. Enhanced antitumor effect of combining interferonβ with TRAIL mediated by tumor-targeting adeno-associated virus vector on A549 lung cancer xenograft. 生物工程学报(英文版). Chin J Biotech 2010, 26(6): 780–788.

Zhong S, Yu D, Wang Y, Qiu S, Wu S, Liu XY. An armed oncolytic adenovirus ZD55-IL-24 combined with ADM or DDP demonstrated enhanced antitumor effect in lung cancer. Acta Oncol. 2010, 49(1): 91-9.

van der Laan LJ*, Wang Y*, Tilanus HW, Janssen HL, Pan Q. AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application? Expert Opin Biol Ther. 2011, 11(3):315-27. (* as first co-author)

He G, Lei W, Wang S, Xiao R, Guo K, Xia Y, Zhou X, Zhang K, Liu X, WangY*. Overexpression of tumor suppressor TSLC1 by a survivin-regulated oncolytic adenovirus significantly inhibits hepatocellular carcinoma growth. J Cancer Res Clin Oncol. 2012 Apr;138(4):657-70

Zhou XM, Xie GL, Wang SB, Wang YG, Zhang KJ, et al. Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene. Plos one, 2012, 2012;7(10):e47566.

Shi-bing Wang, Yuan Tan, Wen Lei, Yi-gang Wang, Xiu-mei Zhou, Kang-jian Zhang, Liang Chu, Xin-yuan Liu, Wen-bin Qian (2012) Complete eradication of xenograft hepatoma by oncolytic adenovirus ZD55 harboring TRAIL-IETD-Smac gene with broad antitumor effect. Human Gene Therapy, 23(9): 992-1002.

Lei W, Liu HB, Wang SB, Zhou XM, Zheng SD, Guo KN, Ma BY, Xia YL, Tan WS, Liu XY, Wang YG*. Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model. Acta Pharmacol Sin. 2013 Apr;34(4):531-40.

姓名:王毅刚

性别:男

所在部门:生命科学学院

行政职务:

专业技术职务:教授

人才称号

校521人才培养计划入选

所属学科

【硕士点】
» 生物学

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